Parkinson’s Disease Rigidity: Relation to Brain Connectivity and Motor Performance
Identifieur interne : 000D02 ( Main/Exploration ); précédent : 000D01; suivant : 000D03Parkinson’s Disease Rigidity: Relation to Brain Connectivity and Motor Performance
Auteurs : Nazanin Baradaran [Canada] ; Sun Nee Tan [Canada] ; Aiping Liu [Canada] ; Ahmad Ashoori [Canada] ; Samantha J. Palmer [Canada] ; Z. Jane Wang [Canada] ; Meeko M. K. Oishi [États-Unis] ; Martin J. Mckeown [Canada]Source :
- Frontiers in Neurology [ 1664-2295 ] ; 2013.
Abstract
Url:
DOI: 10.3389/fneur.2013.00067
PubMed: 23761780
PubMed Central: 3672800
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinson’s Disease Rigidity: Relation to Brain Connectivity and Motor Performance</title><author><name sortKey="Baradaran, Nazanin" sort="Baradaran, Nazanin" uniqKey="Baradaran N" first="Nazanin" last="Baradaran">Nazanin Baradaran</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Pacific Parkinson’s Research Centre, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Sun Nee" sort="Tan, Sun Nee" uniqKey="Tan S" first="Sun Nee" last="Tan">Sun Nee Tan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Pacific Parkinson’s Research Centre, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Aiping" sort="Liu, Aiping" uniqKey="Liu A" first="Aiping" last="Liu">Aiping Liu</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Electrical and Computer Engineering, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ashoori, Ahmad" sort="Ashoori, Ahmad" uniqKey="Ashoori A" first="Ahmad" last="Ashoori">Ahmad Ashoori</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Electrical and Computer Engineering, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Palmer, Samantha J" sort="Palmer, Samantha J" uniqKey="Palmer S" first="Samantha J." last="Palmer">Samantha J. Palmer</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Pacific Parkinson’s Research Centre, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Z Jane" sort="Wang, Z Jane" uniqKey="Wang Z" first="Z. Jane" last="Wang">Z. Jane Wang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Electrical and Computer Engineering, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oishi, Meeko M K" sort="Oishi, Meeko M K" uniqKey="Oishi M" first="Meeko M. K." last="Oishi">Meeko M. K. Oishi</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Electrical and Computer Engineering, University of New Mexico</institution>,<addr-line>Albuquerque, NM</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J." last="Mckeown">Martin J. Mckeown</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Pacific Parkinson’s Research Centre, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Electrical and Computer Engineering, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Medicine (Neurology), University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23761780</idno><idno type="pmc">3672800</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672800</idno><idno type="RBID">PMC:3672800</idno><idno type="doi">10.3389/fneur.2013.00067</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000980</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000980</idno><idno type="wicri:Area/Pmc/Curation">000980</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000980</idno><idno type="wicri:Area/Pmc/Checkpoint">000606</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000606</idno><idno type="wicri:Area/Ncbi/Merge">001476</idno><idno type="wicri:Area/Ncbi/Curation">001476</idno><idno type="wicri:Area/Ncbi/Checkpoint">001476</idno><idno type="wicri:Area/Main/Merge">000D11</idno><idno type="wicri:Area/Main/Curation">000D02</idno><idno type="wicri:Area/Main/Exploration">000D02</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Parkinson’s Disease Rigidity: Relation to Brain Connectivity and Motor Performance</title><author><name sortKey="Baradaran, Nazanin" sort="Baradaran, Nazanin" uniqKey="Baradaran N" first="Nazanin" last="Baradaran">Nazanin Baradaran</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Pacific Parkinson’s Research Centre, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Sun Nee" sort="Tan, Sun Nee" uniqKey="Tan S" first="Sun Nee" last="Tan">Sun Nee Tan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Pacific Parkinson’s Research Centre, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Aiping" sort="Liu, Aiping" uniqKey="Liu A" first="Aiping" last="Liu">Aiping Liu</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Electrical and Computer Engineering, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ashoori, Ahmad" sort="Ashoori, Ahmad" uniqKey="Ashoori A" first="Ahmad" last="Ashoori">Ahmad Ashoori</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Electrical and Computer Engineering, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Palmer, Samantha J" sort="Palmer, Samantha J" uniqKey="Palmer S" first="Samantha J." last="Palmer">Samantha J. Palmer</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Pacific Parkinson’s Research Centre, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Z Jane" sort="Wang, Z Jane" uniqKey="Wang Z" first="Z. Jane" last="Wang">Z. Jane Wang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Electrical and Computer Engineering, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oishi, Meeko M K" sort="Oishi, Meeko M K" uniqKey="Oishi M" first="Meeko M. K." last="Oishi">Meeko M. K. Oishi</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Electrical and Computer Engineering, University of New Mexico</institution>,<addr-line>Albuquerque, NM</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J." last="Mckeown">Martin J. Mckeown</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Pacific Parkinson’s Research Centre, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Electrical and Computer Engineering, University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Medicine (Neurology), University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Neurology</title><idno type="eISSN">1664-2295</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Objective:</bold> (1) To determine the brain connectivity pattern associated with clinical rigidity scores in Parkinson’s disease (PD) and (2) to determine the relation between clinically assessed rigidity and quantitative metrics of motor performance.</p><p><bold>Background:</bold> Rigidity, the resistance to passive movement, is exacerbated in PD by asking the subject to move the contralateral limb, implying that rigidity involves a distributed brain network. Rigidity mainly affects subjects when they attempt to move; yet the relation between clinical rigidity scores and quantitative aspects of motor performance are unknown.</p><p><bold>Methods:</bold> Ten clinically diagnosed PD patients (off-medication) and 10 controls were recruited to perform an fMRI squeeze-bulb tracking task that included both visually guided and internally guided features. The direct functional connectivity between anatomically defined regions of interest was assessed with Dynamic Bayesian Networks (DBNs). Tracking performance was assessed by fitting Linear Dynamical System (LDS) models to the motor performance, and was compared to the clinical rigidity scores. A cross-validated Least Absolute Shrinkage and Selection Operator (LASSO) regression method was used to determine the brain connectivity network that best predicted clinical rigidity scores.</p><p><bold>Results:</bold> The damping ratio of the LDS models significantly correlated with clinical rigidity scores (<italic>p</italic> = 0.014). An fMRI connectivity network in subcortical and primary and premotor cortical regions accurately predicted clinical rigidity scores (<italic>p</italic> < 10<sup>−5</sup>).</p><p><bold>Conclusion:</bold> A widely distributed cortical/subcortical network is associated with rigidity observed in PD patients, which reinforces the importance of altered functional connectivity in the pathophysiology of PD. PD subjects with higher rigidity scores tend to have less overshoot in their tracking performance, and damping ratio may represent a robust, quantitative marker of the motoric effects of increasing rigidity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Berardelli, A" uniqKey="Berardelli A">A. Berardelli</name></author><author><name sortKey="Sabra, A F" uniqKey="Sabra A">A. F. Sabra</name></author><author><name sortKey="Hallett, M" uniqKey="Hallett M">M. Hallett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bezard, E" uniqKey="Bezard E">E. Bezard</name></author><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S. Przedborski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blakemore, S J" uniqKey="Blakemore S">S. J. Blakemore</name></author><author><name sortKey="Frith, C D" uniqKey="Frith C">C. D. 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Miall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Eimeren, T" uniqKey="Van Eimeren T">T. van Eimeren</name></author><author><name sortKey="Monchi, O" uniqKey="Monchi O">O. Monchi</name></author><author><name sortKey="Ballanger, B" uniqKey="Ballanger B">B. Ballanger</name></author><author><name sortKey="Strafella, A P" uniqKey="Strafella A">A. P. Strafella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Gemmert, A W A" uniqKey="Van Gemmert A">A. W. A. Van Gemmert</name></author><author><name sortKey="Adler, C H" uniqKey="Adler C">C. H. Adler</name></author><author><name sortKey="Stelmach, G E" uniqKey="Stelmach G">G. E. Stelmach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, D D" uniqKey="Webster D">D. D. Webster</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Baradaran, Nazanin" sort="Baradaran, Nazanin" uniqKey="Baradaran N" first="Nazanin" last="Baradaran">Nazanin Baradaran</name></noRegion><name sortKey="Ashoori, Ahmad" sort="Ashoori, Ahmad" uniqKey="Ashoori A" first="Ahmad" last="Ashoori">Ahmad Ashoori</name><name sortKey="Liu, Aiping" sort="Liu, Aiping" uniqKey="Liu A" first="Aiping" last="Liu">Aiping Liu</name><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J." last="Mckeown">Martin J. Mckeown</name><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J." last="Mckeown">Martin J. Mckeown</name><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J." last="Mckeown">Martin J. Mckeown</name><name sortKey="Palmer, Samantha J" sort="Palmer, Samantha J" uniqKey="Palmer S" first="Samantha J." last="Palmer">Samantha J. Palmer</name><name sortKey="Tan, Sun Nee" sort="Tan, Sun Nee" uniqKey="Tan S" first="Sun Nee" last="Tan">Sun Nee Tan</name><name sortKey="Wang, Z Jane" sort="Wang, Z Jane" uniqKey="Wang Z" first="Z. Jane" last="Wang">Z. Jane Wang</name></country><country name="États-Unis"><noRegion><name sortKey="Oishi, Meeko M K" sort="Oishi, Meeko M K" uniqKey="Oishi M" first="Meeko M. K." last="Oishi">Meeko M. K. Oishi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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